Predisposing Role of Heterozygote Mthfr A1298c Mutation in Venous Thrombosis in a Pregnant Patient: a Case Report
نویسندگان
چکیده
Congenital and acquired thrombophilia are associated with an increased risk of pregnancy-associated venous thrombosis (VT). Several genetic mechanisms have been investigated for their possible relationship with VT. Methyl tetrahydrofolate reductase gene polymorphisms are frequently in the MTHFR gene, which leads to a C to T change at position 677, has been suggested to alter the thrombohemostasis process and thrombophilia. Also, it has been found that MTHFR C1298C or MTHFR A1298C have no effect on the risk of VT. Herein, we describe deep VT (DVT) secondary to heterozygous MTHFR A1298C mutation in pregnant woman. KEY-WORDS: Pregnancy; MTHFR A1298C Mutation; Venous Thrombosis
منابع مشابه
Heterozygous MTHFR A1298C Mutation causing Cerebral Venous Sinus Thrombosis.
A 21 year college student came with a history of generalized tonic-clonic seizures. MR Venography revealed the presence of left sigmoid and transverse sinus thrombosis with secondary venous hemorrhagic infarcts. After thorough investigation into cause of thrombosis patient was found to have a heterozygous MTHFR A1298C mutation which was causing cerebral venous sinus thrombosis.
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